Table 2.
Multivariable-adjusted hazard ratios for risk of ESKD for models 1–4
| Variable | Model 1 | Model 2 | Model 3 | Model 4 |
|---|---|---|---|---|
| Age | 0.97 (0.95–1.00, P = 0.031) | 0.98 (0.95–1.00, P = 0.100) | 0.98 (0.95–1.01, P = 0.227) | 0.98 (0.96–1.01, P = 0.308) |
| Sex | 0.73 (0.38–1.39, P = 0.336) | 0.66 (0.33–1.29, P = 0.220) | 0.63 (0.31–1.29, P = 0.208) | 0.52 (0.25–1.08, P = 0.080) |
| MPO positive | 0.53 (0.28–1.01, P = 0.055) | 1.42 (0.66–3.09, P = 0.371) | 1.69 (0.78–3.68, P = 0.186) | 1.70 (0.78–3.70, P = 0.184) |
| eGFR (log) | 0.30 (0.19–0.47, P < 0.001) | 0.43 (0.25–0.74, P = 0.002) | 0.53 (0.27–1.05, P = 0.068) | 0.52 (0.25–1.07, P = 0.077) |
| uPCR (log) | 1.60 (1.04–2.44, P = 0.031) | 1.43 (0.94–2.19, P = 0.098) | 1.34 (0.88–2.03, P = 0.177) | 1.31 (0.88–1.97, P = 0.186) |
| ARRS category medium | 3.80 (1.00–14.34, P = 0.049) | 4.14 (1.07–16.01, P = 0.039) | 4.24 (1.06–16.89, P = 0.040) | |
| ARRS category high | 12.97 (2.50–67.28, P = 0.002) | 16.69 (2.91–95.81, P = 0.002) | 18.91 (3.07–116.34, P = 0.002) | |
| CYC | 3.61 (0.68–19.26, P = 0.133) | 4.28 (0.69–26.45, P = 0.118) | ||
| KRT at baseline | 2.80 (1.03–7.66, P = 0.044) | 2.61 (0.97–6.97, P = 0.056) | ||
| PEX | 0.49 (0.17–1.44, P = 0.193) | 0.52 (0.19–1.45, P = 0.213) | ||
| SIMD 1st Quintile | 2.15 (0.59–7.82, P = 0.246) | |||
| SIMD 2nd Quintile | 2.68 (0.80–8.98, P = 0.110) | |||
| SIMD 3rd Quintile | 3.16 (0.82–12.27, P = 0.096) | |||
| SIMD 4th Quintile | 3.47 (1.01–11.96, P = 0.049) |
ARRS, ANCA Renal Risk Score; CYC, cyclophosphamide; eGFR, estimated glomerular filtration rate; KRT, kidney replacement therapy; MPO, myeloperoxidase; PEX, plasma exchange; SIMD, Scottish Index of Multiple Deprivation; uPCR, urinary protein-to- creatinine ratio.
Adjusted hazard ratios for the risk of developing ESKD for models 1–4. Model 1 – adjusted for age, sex, ANCA subtype, eGFR and uPCR. Model 2 – model 1 plus ARRS category. Model 3 – model 2 plus treatment modalities (CYC, RTX, PEX, baseline KRT). Model 4 – model 3 plus SIMD quintile. All data are displayed as hazard ratio (confidence intervals, P-value). Hazard ratios calculated for MPO-ANCA subtype with PR3-ANCA subtype group as reference. Hazard ratios calculated for ARRS Category Medium and ARRS Category High, using ARRS Category Low as reference. Hazard ratios calculated for SIMD quintiles 1–4 using quintile 5 (i.e., least deprived quintile) as reference.