Table 2.

Summary of domain-specific research opportunities.

Domain	Future research opportunities
Air quality	Investigate the added value to other asthma monitoring tools and the application or air quality monitoring in multiparameter asthma interventions
Airway inflammation markers	Not applicable
Lung function	Investigate the effects on asthma outcomes of home-monitoring interventions where patients perform additional lung function measurements when they experience symptoms or measure reversibility
Physical activity	Perform a systematic evaluation of the relation between physical activity and asthma control Investigate how physical activity monitoring can be applied to benefit asthma outcomes
Sleep	Investigate what sleep parameters are most strongly related to asthma control and asthma manifestations Investigate what factors influence the relation between sleep parameters and asthma control in children with asthma, such as age, sleep behavior, and chronic rhinitis
Audiovisual	Investigate if there are specific patient characteristics (eg, age, sex, and asthma severity) to identify children who benefit most from audiovisual monitoring Investigate the added value of visual recordings compared to audio recordings alone
Other physiological measurements	Investigate the added value of other physiological parameters (such as heart rate, respiratory rate, pulse oximetry, and electromyography) in asthma monitoring Investigate the added value of other physiological measurements in a multiparameter asthma monitoring strategy at home.
Questionnaires	Investigate if there are specific patient characteristics (eg, age, sex, and asthma severity) that can identify children with a good symptom perception who can be adequately monitored by questionnaires and children with a poor symptom perception who require additional monitoring Investigate the added value of questionnaire monitoring in multiparameter asthma monitoring
Medication monitoring	Investigate the long-term effects of medication monitoring interventions on adherence and asthma outcomes Investigate the best personalized strategies to provide feedback based on medication monitoring data to optimize adherence
Digital environment	Investigate which components of digital environments are most effective Investigate how digital environments for pediatric asthma can be optimized to maximize effectiveness for health outcomes