Table 1. Vital Status and Sociodemographic and Clinical Characteristics by Race and Ethnicity Among Persons Diagnosed at Age 20 Years or Older With SPCs From 2000 to 2013 in 18 SEER Registries.
| Characteristic | Race and ethnicitya | ||||
|---|---|---|---|---|---|
| Asian or Pacific Islander (n = 10 294) | Black (n = 22 077) | Hispanic (n = 14 840) | White (n = 183 159) | Total (N = 230 370) | |
| Follow-up, median (IQR), mo | 60 (12-96) | 38 (9-86) | 55 (12-92) | 55 (12-94) | 54 (12-93) |
| Vital status and cause of death | |||||
| Alive | 4199 (40.8) | 6600 (29.9) | 5807 (39.1) | 63 617 (34.7) | 80 223 (34.8) |
| Cause of death | |||||
| Cancer | 4794 (46.6) | 11 811 (53.5) | 7041 (47.4) | 86 111 (47.0) | 109 757 (47.6) |
| Cardiovascular disease | 594 (5.8) | 1737 (7.9) | 853 (5.7) | 15 099 (8.2) | 18 283 (7.9) |
| Other | 707 (6.9) | 1929 (8.7) | 1139 (7.7) | 18 332 (10.0) | 22 107 (9.6) |
| Age at SPC diagnosis, y | |||||
| 20-49 | 870 (8.5) | 1526 (6.9) | 1609 (10.8) | 8114 (4.4) | 12 119 (5.3) |
| 50-64 | 2781 (27.0) | 7055 (32.0) | 4143 (27.9) | 43 123 (23.5) | 57 102 (24.8) |
| 65-74 | 2957 (28.7) | 7532 (34.1) | 4481 (30.2) | 59 074 (32.3) | 74 044 (32.1) |
| ≥75 | 3686 (35.8) | 5964 (27.0) | 4607 (31.0) | 72 848 (39.8) | 87 105 (37.8) |
| Year at SPC diagnosis | |||||
| 2000-2004 | 1327 (12.9) | 3319 (15.0) | 1923 (13.0) | 28 200 (15.4) | 34 769 (15.1) |
| 2005-2009 | 3974 (38.6) | 8728 (39.5) | 5610 (37.8) | 72 576 (39.6) | 90 888 (39.5) |
| 2010-2013 | 4993 (48.5) | 10 030 (45.4) | 7307 (49.2) | 82 383 (45.0) | 104 713 (45.5) |
| Sex | |||||
| Female | 5047 (49.0) | 9086 (41.2) | 7070 (47.6) | 74 652 (40.8) | 95 855 (41.6) |
| Male | 5247 (51.0) | 12 991 (58.8) | 7770 (52.4) | 108 507 (59.2) | 134 515 (58.4) |
| Annual household income, $ | |||||
| <35 000-59 999 | 594 (5.8) | 9675 (43.8) | 3410 (23.0) | 57 702 (31.5) | 71 381 (31.0) |
| 60 000-74 999 | 4157 (40.4) | 8590 (38.9) | 7811 (52.6) | 69 232 (37.8) | 89 790 (39.0) |
| ≥75 000 | 5543 (53.8) | 3810 (17.3) | 3609 (24.3) | 56 203 (30.7) | 69 165 (30.0) |
| Unknown | 0 | 2 (<0.1) | 10 (<0.1) | 22 (<0.1) | 34 (<0.1) |
| Urbanicity | |||||
| Large metropolitan | 7184 (69.8) | 14 982 (67.9) | 10 255 (69.1) | 106 398 (58.1) | 138 819 (60.3) |
| Small metropolitan | 2694 (26.2) | 5189 (23.5) | 3879 (26.1) | 51 136 (27.9) | 62 898 (27.3) |
| Nonmetropolitan | 416 (4.0) | 1904 (8.6) | 696 (4.7) | 25 603 (14.0) | 28 619 (12.4) |
| Unknown | 0 | 2 (<0.1) | 10 (0.1) | 22 (<0.1) | 34 (<0.1) |
| SPC type | |||||
| Lung and bronchus | 1958 (19.0) | 5196 (23.5) | 2242 (15.1) | 38 670 (21.1) | 48 066 (20.9) |
| Breast | 1786 (17.3) | 3300 (14.9) | 2496 (16.8) | 22 253 (12.1) | 29 835 (13.0) |
| Colon and rectum | 1560 (15.2) | 3453 (15.6) | 2135 (14.4) | 21 275 (11.6) | 28 423 (12.3) |
| Prostate | 823 (8.0) | 2702 (12.2) | 1530 (10.3) | 20 059 (11.0) | 25 114 (10.9) |
| Urinary bladder | 716 (7.0) | 1314 (6.0) | 1143 (7.7) | 18 273 (10.0) | 21 446 (9.3) |
| Non-Hodgkin lymphoma | 679 (6.6) | 1098 (5.0) | 1218 (8.2) | 13 353 (7.3) | 16 348 (7.1) |
| Melanoma of the skin | 92 (0.9) | 104 (0.5) | 334 (2.3) | 15 901 (8.7) | 16 431 (7.1) |
| Kidney and renal pelvis | 443 (4.3) | 1609 (7.3) | 1091 (7.4) | 9169 (5.0) | 12 312 (5.3) |
| Oral cavity and pharynx | 399 (3.9) | 752 (3.4) | 461 (3.1) | 6611 (3.6) | 8223 (3.6) |
| Pancreas | 392 (3.8) | 911 (4.1) | 537 (3.6) | 5864 (3.2) | 7704 (3.3) |
| Stomach | 566 (5.5) | 771 (3.5) | 581 (3.9) | 3227 (1.8) | 5145 (2.2) |
| Thyroid | 511 (5.0) | 379 (1.7) | 645 (4.3) | 4400 (2.4) | 5935 (2.6) |
| Corpus uteri and uterus, not otherwise specified | 369 (3.6) | 488 (2.2) | 427 (2.9) | 4104 (2.2) | 5388 (2.3) |
| Stage at SPC diagnosis | |||||
| Localized | 5212 (50.6) | 10 622 (48.1) | 7591 (51.2) | 100 725 (55.0) | 124 150 (53.9) |
| Regional | 2214 (21.5) | 4635 (21.0) | 3130 (21.1) | 34 740 (19.0) | 44 719 (19.4) |
| Distant | 1980 (19.2) | 4945 (22.4) | 2772 (18.7) | 33 308 (18.2) | 43 005 (18.7) |
| Unknown or unstaged | 633 (6.1) | 1225 (5.5) | 994 (6.7) | 8985 (4.9) | 11 837 (5.1) |
| Blankb | 255 (2.5) | 650 (2.9) | 353 (2.4) | 5401 (2.9) | 6659 (2.9) |
| Surgery for SPC | |||||
| Performed | 6487 (63.0) | 11 807 (53.5) | 9149 (61.7) | 114 308 (62.4) | 141 751 (61.5) |
| Not performed | 3661 (35.6) | 10 062 (45.6) | 5560 (37.5) | 67 207 (36.7) | 86 490 (37.5) |
| Unknown | 146 (1.4) | 208 (0.9) | 131 (0.9) | 1644 (0.9) | 2129 (0.9) |
| Radiotherapy for SPC | |||||
| Yes | 2289 (22.2) | 5103 (23.1) | 2914 (19.6) | 38 485 (21.0) | 48 791 (21.2) |
| None or unknown | 8005 (77.8) | 16 974 (76.9) | 11 926 (80.4) | 144 674 (79.0) | 181 579 (78.8) |
| Chemotherapy for SPC | |||||
| Yes | 2683 (26.1) | 5870 (26.6) | 3670 (24.7) | 40 783 (22.3) | 53 006 (23.0) |
| No or unknown | 7611 (73.9) | 16 207 (73.4) | 11 170 (75.3) | 142 376 (77.7) | 177 364 (77.0) |
| Time between prior cancer diagnosis and SPC diagnosis, y | |||||
| 0-4.9 | 6910 (67.1) | 14 707 (66.6) | 10 000 (67.4) | 122 511 (66.9) | 154 128 (66.9) |
| 5-9.9 | 2824 (27.4) | 6107 (27.7) | 3955 (26.7) | 50 067 (27.3) | 62 953 (27.3) |
| ≥10 | 560 (5.4) | 1263 (5.7) | 885 (6.0) | 10 581 (5.8) | 13 289 (5.8) |
| Prior cancer type | |||||
| Genital system | 2271 (22.1) | 6829 (30.9) | 3599 (24.3) | 42 474 (23.2) | 55 173 (23.9) |
| Breast | 2162 (21.0) | 3975 (18.0) | 2907 (19.6) | 27 861 (15.2) | 36 905 (16.0) |
| Digestive system | 2195 (21.3) | 3738 (16.9) | 2566 (17.3) | 24 000 (13.1) | 32 499 (14.1) |
| Urinary system | 1041 (10.1) | 2244 (10.2) | 1905 (12.8) | 26 117 (14.3) | 31 307 (13.6) |
| Respiratory system | 762 (7.4) | 2102 (9.5) | 869 (5.9) | 16 105 (8.8) | 19 838 (8.6) |
| Lymphoma, myeloma, or leukemia | 698 (6.8) | 1490 (6.7) | 1290 (8.7) | 14 872 (8.1) | 18 350 (8.0) |
| Skin or eye | 115 (1.1) | 137 (0.6) | 373 (2.5) | 16 237 (8.9) | 16 862 (7.3) |
| Oral cavity and pharynx | 411 (4.0) | 698 (3.2) | 426 (2.9) | 6606 (3.6) | 8141 (3.5) |
| Endocrine system | 352 (3.4) | 299 (1.4) | 442 (3.0) | 3446 (1.9) | 4539 (2.0) |
| Bones and joints or soft tissue including heart | 53 (0.5) | 115 (0.5) | 130 (0.9) | 1037 (0.6) | 1335 (0.6) |
| Brain and other nervous system | 23 (0.2) | 34 (0.2) | 35 (0.2) | 437 (0.2) | 529 (0.2) |
| Other | 211 (2.0) | 416 (1.9) | 298 (2.0) | 3967 (2.2) | 4892 (2.1) |
| Age at prior cancer diagnosis, y | |||||
| 20-49 | 1354 (13.2) | 2523 (11.4) | 2372 (16.0) | 14 087 (7.7) | 20 336 (8.8) |
| 50-64 | 3319 (32.2) | 8790 (39.8) | 4965 (33.5) | 57 914 (31.6) | 74 988 (32.6) |
| 65-74 | 3102 (30.1) | 7157 (32.4) | 4499 (30.3) | 62 025 (33.9) | 76 783 (33.3) |
| ≥75 | 2519 (24.5) | 3607 (16.3) | 3004 (20.2) | 49 133 (26.8) | 58 263 (25.3) |
| Year at prior cancer diagnosis | |||||
| 2000-2004 | 4942 (48.0) | 11 243 (50.9) | 6956 (46.9) | 95 603 (52.2) | 118 744 (51.5) |
| 2005-2009 | 3993 (38.8) | 8215 (37.2) | 5794 (39.0) | 66 828 (36.5) | 84 830 (36.8) |
| 2010-2013 | 1359 (13.2) | 2619 (11.9) | 2090 (14.1) | 20 728 (11.3) | 26 796 (11.6) |
| Stage at prior cancer diagnosis | |||||
| Localized | 5870 (57.0) | 13 113 (59.4) | 8426 (56.8) | 116 647 (63.7) | 144 056 (62.5) |
| Regional | 2504 (24.3) | 4785 (21.7) | 3471 (23.4) | 34 683 (18.9) | 45 443 (19.7) |
| Distant | 777 (7.5) | 1885 (8.5) | 1244 (8.4) | 11 968 (6.5) | 15 874 (6.9) |
| Unknown or unstaged | 329 (3.2) | 804 (3.6) | 577 (3.9) | 5009 (2.7) | 6719 (2.9) |
| Blankb | 814 (7.9) | 1490 (6.7) | 1122 (7.6) | 14 852 (8.1) | 18 278 (7.9) |
Abbreviations: SEER, Surveillance, Epidemiology, and End Results; SPC, second primary cancer.
a
Data are presented as number (percentage) of persons unless otherwise indicated. All race categories are exclusive of Hispanic ethnicity.
b
Cases with certain site and/or year combinations that were not covered by SEER historic stage A were coded as blank, including 3716 oral cancer cases for certain subsites from 2004 to 2013 and 2943 chronic lymphocytic leukemia cases.26