. 2023 Aug 4;6(8):e2327429. doi: 10.1001/jamanetworkopen.2023.27429

Table 2. Association of Race and Ethnicity With Risk of Death From Cancer or CVD Among Persons Diagnosed at Age 20 Years or Older With SPCs From 2000 to 2013 in 18 SEER Registries.

Cause of death, race and ethnicity^a	Deaths, No./total No. (%)	HR (95% CI)			HR reduction from model 1 to model 3, %^e
Cause of death, race and ethnicity^a	Deaths, No./total No. (%)	Model 1^b	Model 2^c	Model 3^d	HR reduction from model 1 to model 3, %^e
Cancer
Asian or Pacific Islander	5500/10 294 (53.4)	0.93 (0.90-0.96)	0.98 (0.95-1.01)	0.90 (0.86-0.93)	NC
Black	10 266/22 077 (46.5)	1.21 (1.18-1.23)	1.19 (1.17-1.21)	1.08 (1.05-1.11)	61.0
Hispanic	7799/14 840 (52.6)	1.10 (1.07-1.13)	1.11 (1.09-1.14)	1.04 (1.00-1.07)	63.4
White	97 048/183 159 (53.0)	1 [Reference]	1 [Reference]	1 [Reference]	NC
CVD
Asian or Pacific Islander	594/10 294 (5.8)	0.75 (0.69-0.81)	0.78 (0.72-0.85)	0.78 (0.69-0.87)	NC
Black	1737/22 077 (7.9)	1.41 (1.34-1.49)	1.39 (1.32-1.46)	1.30 (1.21-1.4)	26.7
Hispanic	853/14 840 (5.7)	0.90 (0.84-0.96)	0.90 (0.84-0.97)	0.89 (0.8-0.98)	NC
White	15 099/183 159 (8.2)	1 [Reference]	1 [Reference]	1 [Reference]	NC

Abbreviations: CVD, cardiovascular diease; HR, hazard ratio; NC, not calculated; SEER, Surveillance, Epidemiology, and End Results; SPC, second primary cancer.

^{^a}

All race categories are exclusive of Hispanic ethnicity.

^{^b}

Adjusted for sex (female, male), prior cancer type or system (eTable 3 in Supplement 1), prior cancer stage (localized, regional, distant, unknown or unstaged, or blank), and year (2000-2004, 2005-2009, or 2010-2013) and age (5-year interval) at SPC diagnosis.

^{^c}

Adjusted for the variables in model 1 and county-level annual household income (<$35 000-$59 000, $60 000-$74 999, ≥$75 000, or unknown) and county-level urbanity (large metropolitan, small metropolitan, nonmetropolitan, or unknown).

^{^d}

Adjusted for the variables in model 2 and SPC type, stage, subtype (eTable 4 in Supplement 1), and treatment (including receipt of surgery, radiotherapy, or chemotherapy for SPC).

^{^e}

Calculated using the formula only when the HRs in models 1 and 3 were higher than 1.00: [model 1 HR − model 3 HR] / [model 1 HR] × 100.