TABLE 2.
Patient Baseline Characteristics by bDMARD Fill Status
| All Patients (N = 373) | Early Biologic Fillersa(n = 170) | Late Biologic Fillersb(n = 59) | Nonfillersc(n = 144) | Late Biologic Fillers and Nonfillers Combined (n = 203) | |
|---|---|---|---|---|---|
| Age in years, mean (SD) | 57.1 (14.7) | 51.6 (13.4) | 55.9 (15.7) | 64.0 (12.8) | 61.7 (14.1) |
| Sex, n (%) | |||||
| Female | 274 (73.5) | 128 (75.3) | 40 (67.8) | 106 (73.6) | 146 (71.9) |
| Race, n (%) | |||||
| African American | 15 (4.0) | 9 (5.3) | 2 (3.4) | 4 (2.8) | 6 (3.0) |
| Asian | 4 (1.1) | 2 (1.2) | 0 | 2 (1.4) | 2 (1.0) |
| White | 297 (79.6) | 131 (77.1) | 48 (81.4) | 118 (81.9) | 166 (81.8) |
| Other/unknown | 57 (15.3) | 28 (16.5) | 9 (15.3) | 20 (13.9) | 29 (14.3) |
| Census Bureau region, n (%) | |||||
| Northeast | 29 (7.8) | 19 (11.2) | 2 (3.4) | 8 (5.6) | 10 (4.9) |
| Midwest | 101 (27.1) | 33 (19.4) | 18 (30.5) | 50 (34.7) | 68 (33.5) |
| South | 160 (42.9) | 85 (50.0) | 30 (50.9) | 45 (31.3) | 75 (37.0) |
| West | 76 (20.4) | 30 (17.7) | 8 (13.6) | 38 (26.4) | 46 (22.7) |
| Other/unknown | 7 (1.9) | 3 (1.8) | 1 (1.7) | 3 (2.1) | 4 (2.0) |
| Household income, mean (SD) | 44,545 (12,370) | 45,689 (14,342) | 42,286 (9,430) | 44,119 (10,722) | 43,585 (10,372) |
| Business type on index date, n (%) | |||||
| Commercial | 226 (60.6) | 140 (82.4) | 38 (64.4) | 48 (33.3) | 86 (42.4) |
| Medicare | 146 (39.1) | 30 (17.7) | 21 (35.6) | 95 (66.0) | 116 (57.1) |
| Medicaid | 1 (0.3) | 0 | 0 | 1 (0.7) | 1 (0.5) |
| Product type on index date, n (%) | |||||
| Health maintenance organization | 125 (33.5) | 40 (23.5) | 14 (23.7) | 71 (49.3) | 85 (41.9) |
| Preferred provider organization | 24 (6.4) | 11 (6.5) | 2 (3.4) | 11 (7.6) | 13 (6.4) |
| Exclusive provider organization | 29 (7.8) | 17 (10.0) | 5 (8.5) | 7 (4.9) | 12 (5.9) |
| Indemnity | 6 (1.6) | 2 (1.2) | 2 (3.4) | 2 (1.4) | 4 (2.0) |
| Point of service | 140 (37.5) | 88 (51.8) | 27 (45.8) | 25 (17.4) | 52 (25.6) |
| Other | 49 (13.1) | 12 (7.1) | 9 (15.3) | 28 (19.4) | 37 (18.2) |
| Pain score during 6 months pre-index, n (%) | 33 (8.9) | 16 (9.4) | 7 (11.9) | 10 (6.9) | 17 (8.4) |
| Pain score, mean (SD) | 4.9 (3.2) | 6.3 (2.2) | 4.4 (3.5) | 2.9 (3.4) | 3.5 (3.4) |
| RA-severity score during 6 months pre-index, mean (SD) | 4.0 (1.8) | 4.7 (1.7) | 4.4 (1.6) | 3.2 (1.5) | 3.5 (1.6) |
| Number of monthly prescriptions during 6 months pre-index, mean (SD) | |||||
| Humedica (EHR) | 1.6 (1.8) | 1.7 (2.0) | 1.5 (1.6) | 1.4 (1.8) | 1.4 (1.7) |
| Optum (claims) | 3.1 (3.0) | 3.9 (3.1) | 3.5 (2.7) | 2.1 (2.8) | 2.5 (2.8) |
| Number of rheumatology visits during 6 months pre-index, mean (SD) | 1.1 (2.0) | 1.2 (2.0) | 1.5 (2.4) | 0.8 (1.6) | 1.0 (1.9) |
abDMARD prescription filled within 30 days of index bDMARD.
bbDMARD prescription filled within 31-180 days of index bDMARD.
cbDMARD prescription not filled at all within 180 days of index bDMARD.
bDMARD = biologic disease-modifying antirheumatic drug; EHR = Electronic Health Record; RA = rheumatoid arthritis; SD = standard deviation.