Table 3.

Univariable and multivariable logistic regression analyses regarding primary and secondary outcomes (n = 762)

Primary outcomes
	Univariable model			Multivariable model* corrected for the influence of both centers
Potential predictors of outcome/confounders (as identified in Table 1 and as established in the literature)	OR	95% CI	p value	OR	95% CI	p value
Return to premorbid neurologic function
Female sex	0.78	0.59–1.04	0.089	0.75	0.55–1.02	0.070
Age (per every additional year of age)	0.97	0.97–0.98	< 0.001	0.99	0.98–0.99	0.011
Acute intracranial hemorrhage	0.27	0.16–0.46	< 0.001	0.28	0.16–0.48	< 0.001
SE severity (as quantified by the STESS)	0.36	0.27–0.49	< 0.001	0.49	0.33–0.73	< 0.001
SE type	0.90	0.73–1.11	0.313	1.07	0.83–1.38	0.584
In-hospital death
Female sex	1.34	0.77–2.32	0.295	1.40	0.77–2.53	0.268
Age (per every additional year of age)	1.04	1.02–1.06	< 0.001	1.04	1.01–1.06	0.002
Acute intracranial hemorrhage	2.13	1.08–4.20	0.030	1.87	0.89–3.90	0.097
SE severity (as quantified by the STESS)	5.35	2.49–11.49	< 0.001	1.64	0.64–4.23	0.304
SE type	2.85	1.92–4.23	< 0.001	2.77	1.78–4.32	< 0.001
Death at 30 days follow-up
Female sex	1.34	0.77–2.32	0.295	1.27	0.90–1.80	0.177
Age (per every additional year of age)	1.04	1.02–1.06	< 0.001	1.04	1.03–1.05	< 0.001
Acute intracranial hemorrhage	2.13	1.08–4.20	0.030	1.19	0.72–1.97	0.492
SE severity (as quantified by the STESS)	2.05	1.45–2.89	< 0.001	0.96	0.60–1.52	0.849
SE type	1.26	0.99–1.59	0.059	1.44	1.09–1.90	0.010

Secondary outcomes
	Univariable model			Multivariable model* corrected for the influence of both centers
Potential influences on treatment decisions (as identified in Table 1)	OR	95% CI	p value	OR	95% CI	p value
Use of anesthetics
Female sex	0.55	0.41–0.76	< 0.001	0.64	0.45–0.91	0.013
Age (per every additional year of age)	0.97	0.97–0.98	< 0.001	0.98	0.97–0.99	< 0.001
Acute intracranial hemorrhage	1.50	0.96–2.34	0.073	1.32	0.78–2.21	0.299
SE type	2.77	2.18–3.52	< 0.001	3.35	2.57–4.37	< 0.001
Use of mechanical ventilation
Female sex	0.61	0.45–0.82	0.001	0.72	0.52–1.00	0.050
Age (per every additional year of age)	0.98	0.97–0.99	< 0.001	0.98	0.97–0.99	< 0.001
Acute intracranial hemorrhage	2.39	1.54–3.70	< 0.001	2.46	1.50–4.03	< 0.001
SE type	2.84	2.25–3.60	< 0.001	3.11	2.42–3.99	< 0.001

OR = odds ratio; CI = confidence interval; SE = status epilepticus; STESS = status epilepticus severity score

*All Hosmer–Lemeshow goodness-of-fit tests insignificant indicating adequate model fit

Bold font indicates statistical significance (with a p value set at ≤0.05)