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. 2023 Aug 4;21:286. doi: 10.1186/s12916-023-02959-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — CUS and CSF1Ri enhanced anxiety in mice. (A) Schema representing experimental design. (B) ratio (%) of travel distance in corners (m) against total travel distance (m) in an open field and (C) ratio (%) of time spent in open arms against closed arms in an elevated plus maze (n = 9–10 mice per group). Ctr: Control; CUS: chronic unpredictable stress; CSF1Ri: CSF1R inhibitor; EPM: elevated plus maze; OFT: open field test; Veh: Vehicle. Data presented as mean ± SEM; */**/***/**** p < 0.05/0.01/0.001/0.0001 compared to Ctr-Veh. Two-way ANOVA with Bonferroni’s correction