Table 3.
Multivariate regression results of treatment regimens effect on patient-reported outcomes and HRQoL.
| Variables | Annual bleeds | Chronic pain | Target joints | Disability | EQ-5D | EQ-VAS | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AME | 95%CI | OR | 95%CI | AME | 95%CI | OR | 95%CI | AME | 95%CI | AME | 95%CI | |
| Treatment regimens (vs. On-demand) | ||||||||||||
| Short-term prophylaxis | -37.62*** | -52.91 to -22.33 | 0.34*** | 0.21 to 0.55 | -0.10 | -0.21 to 0.40 | 0.58 | 0.23 to 1.64 | 0.08** | 0.02 to 0.14 | 6.63* | 0.10 to 13.26 |
| Long-term prophylaxis | -52.27*** | -79.26 to -34.28 | 0.08*** | 0.02 to 0.27 | -0.27 | -0.63 to 0.09 | 1.00 | NA | 0.12** | 0.03 to 0.20 | 14.69* | 2.32 to 27.06 |
| Age (vs. 0–4) | ||||||||||||
| 5–9 | 0.31 | -10.50 to 11.11 | 3.63*** | 2.18 to 6.06 | 0.62*** | 0.35 to 0.89 | 2.79 | 0.26 to 29.27 | 0.03 | -0.01 to 0.07 | -0.57 | -6.43 to 5.38 |
| 10–14 | 3.17 | -10.34 to 16.67 | 3.09*** | 1.77 to 5.39 | 1.31*** | 0.91 to 1.71 | 10.64* | 1.24 to 90.93 | 0.05* | 0.01 to 0.09 | 0.64 | -5.97 to 7.25 |
| 15–18 | 3.66 | -10.66 to 17.97 | 16.20*** | 7.91 to 33.18 | 1.84*** | 1.27 to 2.41 | 92.16*** | 8.20 to 103.55 | -0.07 | -0.17 to 0.03 | -9.61* | -18.91 to -0.30 |
| BMI (vs. Underweight) | ||||||||||||
| Normal | 3.24 | -6.97 to 13.45 | 0.93 | 0.60 to 1.44 | 0.06 | -0.20 to 0.32 | 0.53 | 0.13 to 2.02 | 0.01 | -0.04 to 0.04 | 0.08 | -5.23 to 5.40 |
| Overweight | 4.77 | -7.72 to 17.27 | 1.30 | 0.67 to 2.50 | 0.69* | 0.15 to 1.23 | 0.74 | 0.14 to 3.73 | -0.04 | -0.10 to 0.02 | -5.03 | -13.27 to 3.21 |
| Social health insurance (vs. Yes) | ||||||||||||
| No | 2.17 | -19.55 to 23.89 | 0.66 | 0.34 to 1.30 | 0.04 | -0.80 to 0.89 | 1.00 | NA | 0.01 | -0.09 to 0.10 | -1.38 | -13.40 to 10.64 |
| Regional location (vs. East area) | ||||||||||||
| Mid area | 7.00 | -4.15 to 18.14 | 2.38** | 1.40 to 4.07 | 0.41* | 0.05 to 0.76 | 1.28 | 0.35 to 4.62 | -0.06** | -0.10 to -0.01 | -3.10 | -9.11 to 2.90 |
| West area | -4.24 | -15.00 to 6.53 | 2.96*** | 1.79 to 4.89 | 0.47** | 0.12 to 0.82 | 1.16 | 0.32 to 4.09 | -0.06* | -0.11 to -0.01 | -3.04 | -9.52 to 3.44 |
| Hemophilia severity (vs. Moderate) | ||||||||||||
| Severe | 2.63 | -14.17 to 8.90 | 0.89 | 0.55 to 1.44 | 0.28 | -0.03 to 0.59 | 2.75 | 0.82 to 9.22 | 0.01 | -0.02 to 0.04 | 2.96 | -2.27 to 8.20 |
| Infectious blood disease (vs. No) | ||||||||||||
| Yes | -3.61 | -21.11 to 77.84 | 0.51 | 0.15 to 1.71 | -0.06 | -0.55 to 0.44 | 1.00 | NA | -0.02 | -0.12 to 0.09 | -0.59 | -14.27 to 13.08 |
AME, average marginal effect; OR, odds ratio. 95%CI, 95% confidence interval
*p < 0 0.05. **p < 0 0.01. ***p < 0 0.001