TABLE 3.
Virus antigen-positive cells in the CNSa
| Virus | Time (wk) post-infection | No. of antigen-positive cells (avg ± SEM)
|
|
|---|---|---|---|
| Brain | Spinal cord | ||
| pDA | 1 | 36.17 ± 10.15 | 0.17 ± 0.17 |
| 4 | 26.33 ± 5.75 | 117.50 ± 23.03 | |
| 8 | 18.00 ± 7.48 | 64.67 ± 19.70 | |
| T81V | 1 | 26.67 ± 9.80 | 1.50 ± 1.15 |
| 4 | 23.00 ± 8.25 | 56.33 ± 14.15 | |
| 8 | 18.00 ± 4.65 | 19.83 ± 3.60 | |
| T81W | 1 | 15.67 ± 8.00 | 0.83 ± 0.83 |
| 4 | 7.00 ± 4.40 | 0 | |
| 8 | 7.97 ± 3.00 | 4.00 ± 2.97 | |
| T81D | 1 | 12.50 ± 2.95 | 0 |
| 4 | 0.67 ± 0.49 | 0.50 ± 0.50 | |
| 8 | 3.00 ± 1.63 | 0 | |
| V91T | 1 | 0.50 ± 0.22 | 0 |
| 4 | 1.33 ± 0.84 | 0 | |
| 8 | 0.83 ± 0.48 | 0 | |
a
The brains and spinal cords were cut into 5 and 10 coronal sections, respectively. The same regions for each mouse were examined. The viral antigen-positive cells were detected by immunohistochemistry, and the total numbers of TMEV antigen-positive cells in the brain and spinal cord of each mouse were enumerated in a light microscope at a magnification of ×200.