Table 1.
Comparison of baseline data between PSD group and Non-PSD group
| Variables | All patients (n = 358) |
PSD group (n = 92) |
Non-PSD group (n = 266) |
P value |
|---|---|---|---|---|
| Demographic data | ||||
| Age, years | 65 (59, 70) | 66 (60, 71) | 64 (59, 70) | 0.169 |
| Female (%) | 166 (46.4) | 57 (62.0) | 109 (41.0) | 0.001 |
| Education, years | 4 (1, 6) | 3 (0, 6) | 5 (2, 6) | 0.020 |
| Married (%) | 348 (97.2) | 89 (96.7) | 259 (97.4) | 0.752 |
| BMI, kg/m² | 24.77 (23.22, 26.87) | 24.50 (23.08, 26.67) | 24.87 (23.23, 26.92) | 0.789 |
| Hospitalization days, days | 12 (10, 14) | 13 (10, 15) | 12 (10, 14) | 0.205 |
| Vascular risk factors | ||||
| Hypertension (%) | 280 (78.2) | 71 (77.2) | 209 (78.6) | 0.780 |
| Diabetes (%) | 104 (29.1) | 24 (26.1) | 80 (30.1) | 0.468 |
| Coronary heart disease (%) | 62 (17.3) | 18 (19.6) | 44 (16.5) | 0.509 |
| Hyperlipidemian (%) | 111 (31.0) | 27 (29.3) | 84 (31.6) | 0.690 |
| Smoking (%) | 106 (29.6) | 25 (27.2) | 81 (30.5) | 0.553 |
| Drinking (%) | 66 (18.4) | 16 (17.4) | 50 (18.8) | 0.764 |
| Stroke subtypes | 0.592 | |||
| LAA (%) | 271 (75.7) | 73 (79.3) | 198 (74.4) | |
| CE (%) | 42 (11.7) | 8 (8.7) | 34 (12.8) | |
| SAO (%) | 33 (9.2) | 7 (7.6) | 26 (9.8) | |
| ESUS (%) | 12 (3.4) | 4 (4.3) | 8 (3.0) | |
| Neuropsychological function | ||||
| NIHSS on admission, score | 2.5 (1, 4) | 3 (2, 5) | 2 (1, 4) | 0.008 |
| BI score at discharge, score | 90 (80, 95) | 85 (70, 90) | 90 (80, 100) | 0.010 |
| mRS score at discharge, score | 1 (1, 2) | 1 (1, 3) | 1 (1, 2) | 0.006 |
| HAMD score, score | 3 (2, 8) | 12 (9, 15) | 2 (1, 4) | <0.001 |
| Laboratory data | ||||
| Leucocyte, ×109 /L | 6.91 (5.67, 8.30) | 6.90 (6.08, 8.41) | 6.95 (5.53, 8.30) | 0.233 |
| Neutrophil, ×109 /L | 4.72 (3.51, 5.76) | 4.82 (4.06, 5.66) | 4.64 (3.32, 5.78) | 0.085 |
| Lymphocyte, ×109 /L | 1.58 (1.23, 2.03) | 1.55 (1.23, 1.89) | 1.59 (1.22, 2.14) | 0.305 |
| Hs-CRP, mg/L | 2.57 (1.05, 3.56) | 2.68 (1.61, 3.95) | 2.57 (0.90, 3.49) | 0.192 |
| LCN2, ng/ml | 121.91 (93.13, 155.20) | 139.90 (118.80, 178.85) | 113.95 (87.99, 143.63) | <0.001 |
| eGFR, ml/min/1.73m2 | 107.82 (87.00, 133.97) | 98.17 (81.32, 119.45) | 112.38 (89.03, 138.97) | 0.001 |
| Infarct volume, mm 3 | 1849.88 (822.79, 4125.00) | 2297.50 (993.10, 5289.86) | 1794.60 (760.80, 3645.08) | 0.029 |
Abbreviations: PSD post-stroke depression, Non-PSD Non-post-stroke depression, BMI body mass index, LAA Large artery atherosclerosis, CE Cardioembolism, SAO small-artery occlusion, ESUS embolic stroke of undetermined source, NIHSS National Institutes of Health Stroke Scale, BI Barthel Index, mRS modified Rankin Scale, HAMD Hamilton Depression Scale, Hs-CRP High-sensitivity C-reactive protein, LCN2 Lipocalin 2, eGFR estimated glomerular filtration rate.