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. 2023 May 30;102(9):1047–1057. doi: 10.1177/00220345231169220

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© International Association for Dental Research and American Association for Dental, Oral, and Craniofacial Research 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Identification of genes with compromised expression in the teeth of autophagy-deficient mice. (A) Schematic diagram of binding sites (BSs) for NRF2 in the promoter region (10 kb upstream from transcription start site) of each gene related to amelogenesis imperfecta. The conserved NRF2 BSs among 8 species were selected for experimental validation. (B) Quantitative reverse transcription polymerase chain reaction analyses for the indicated genes of upper incisors from wild-type (blue bars) and Atg7 cKO (green bars) mice. ***P < 0.001. n = 6 per group. (C) Chromatin immunoprecipitation analyses for each BS in Dlx3, Klk4, Nectin1, Bcl11c, Pax9, and Ltbp3. ***P < 0.001; ns, not significant. n = 6 per group.