Table 6.
Genotype and allele frequency of interleukin-10 polymorphisms (rs1800872 and rs1800896) between cases and controls
| SNP | Genotypes/alleles | Cases, n (%) | Controls, n (%) | P | OR (95% CI) | P | AOR | P |
|---|---|---|---|---|---|---|---|---|
| rs1800872 | CC | 104 (52.2) | 96 (44.6) | 0.07 | Reference | - | - | |
| CA | 73 (36.6) | 94 (43.7) | 0.71 (0.47–1.08) | 0.11 | 0.72 (0.47–1.09) | 0.12 | ||
| AA | 22 (11.1) | 25 (11.6) | 0.81 (0.43–1.53) | 0.52 | 0.94 (0.50–1.75) | 0.84 | ||
| C | 281 (70.6) | 286 (66.5) | 0.23 | Reference | ||||
| A | 117 (29.3) | 144 (33.4) | 0.82 (0.62–1.11) | 0.20 | ||||
| Dominant model | CA+AA | 95 (47.7) | 119 (55.3) | 0.74 (0.50–1.09) | 0.12 | 0.75 (0.50–1.11) | 0.15 | |
| CC | 104 (52.2) | 96 (44.6) | ||||||
| Recessive Model | AA | 22 (11.1) | 25 (11.6) | 0.94 (0.51–1.74) | 0.85 | 0.99 (0.53–1.85) | 0.9 | |
| GG+GA | 177 (88.9) | 190 (88.3) | ||||||
| Co-dominant model | AA | 22 (11.05) | 25 (11.63) | 0.84 (0.61–1.11) | 0.219 | 0.74 (0.49–1.10) | 0.14 | |
| CA | 73 (36.68) | 94 (43.72) | ||||||
| CC | 104 (52.27) | 96 (44.65) | ||||||
| rs1800896 | AA | 72 (36.18) | 110 (51.16) | 0.007* | Reference | |||
| AG | 99 (49.75) | 85 (39.54) | 1.77 (1.17–2.69) | 0.006* | 1.96 (1.27–3.02) | 0.002* | ||
| GG | 28 (14.07) | 20 (9.30) | 2.13 (1.12–4.08) | 0.02* | 2.28 (1.16–4.46) | 0.016* | ||
| A | 243 (61.05) | 305 (70.93) | 0.003* | Reference | ||||
| G | 155 (38.9) | 125 (29.07) | 1.55 (1.16–2.07) | 0.002* | ||||
| Dominant model | AG+GG | 127 (63.82) | 105 (48.84) | 1.85 (1.25–2.74) | 0.002* | 2.01 (1.34–3.03) | 0.001* | |
| AA | 72 (36.18) | 110 (51.16) | ||||||
| Recessive model | GG | 28 (14.07) | 20 (9.30) | 1.6 (0.87–2.94) | 0.13 | 1.73 (0.93–3.24) | 0.08 | |
| AA+AG | 171 (85.93) | 195 (90.70) | ||||||
| Co-dominant model | GG | 28 (14.07) | 20 (9.30) | 1.56 (1.16–2.09) | 0.003* | 1.572 (1.056–2.339) | 0.026* | |
| AG | 99 (49.7) | 85 (39.54) | ||||||
| AA | 72 (36.18) | 110 (51.16) |
*P<0.05. OR=Odds ratio, CI=Confidence interval, AOR=Adjusted OR