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Schematic overview of how loss of heterogeneity may affect the haematopoietic system. The diversity of cell populations within the haematopoietic stem and progenitor pools changes with age. Progressively clonal diversity will change and mosaicism from the clones with shift. Depending on the composition of the clones that comprise our haematopoietic system as we age, our resilience or vulnerability to particular challenges will shift.
