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Release of lactate dehydrogenase (LDH) measured after a 24-h exposure period of human gingival fibroblasts (HGF-1) to a–e nicotine pouch extracts, f reference snus CRP1.1, and g nicotine control in dissolution medium. Nicotine concentrations of sample extracts are represented through the dotted line, plotted against the secondary Y-axis. Results are presented as mean of triplicate and standard deviation. *p < 0.05, **p < 0.01, ***p < 0.001
