Table 1.

Flavor compounds identified in five nicotine pouches using GC/MS

Sample No	Flavor category (Krusemann et al. 2019)	Identified compounds (hazard statements according to CLP)
1.	Spices–Chili	α-terpineol, β-terpineol, benzyl alcohol (H302—Cat. 41, H332—Cat. 44), bornyl acetate, carvone (H317—Cat. 1)3, caryophyllene, cinnamaldehyde, citral (H315—Cat. 22, H317—Cat. 13), dihydrocapsaicin, eugenol, geranyl acetate, limonene (H315—Cat. 22, H317—Cat. 13), linalool (H317—Cat. 1B)3, menthol, n-hexadecanoic acid, tris(2-butoxyethyl) phosphate, terpinen-4-ol
2.	Other beverages–Cola	α-terpineol, β-terpineol, 1-terpinenol, 1,4-cineole, benzyl alcohol (H302—Cat. 41, H332—Cat. 44), benzyl benzoate (H302—Cat. 41), camphene, carvone (H317—Cat. 1)3, eucalyptol, isopulegol, linalool (H317—Cat. 1B)3, menthol, neryl acetate, octanal propylene glycol acetale, tris(2-butoxyethyl) phosphate, terpinen-4-ol
3.	Tobacco	α-terpineol, β-bourbonene, cis-β-farnesene, β-terpineol, benzyl alcohol (H302—Cat. 41, H332—Cat. 44), benzaldehyde (H302—Cat. 4)1, carvone (H317—Cat. 1)3, carvyl acetate, cis-carveol, caryophyllene, dihydrocarvone, eucalyptol, humulene, isomenthyl acetate, isopulegol, limonene (H315—Cat. 22, H317—Cat.13), linalool (H317—Cat. 1)3, menthol, menthone, neomenthol, neomenthyl acetate, piperitone, pulegone, terpinen-4-ol
4.	Menthol	α-terpineol, β-pinene, γ-elemene, 3-methyl cyclohexanone, artemisia triene, β-bourbonene, butyl palmitate, butylated hydroxytoluene, carvone (H317—Cat. 1)3, caryophyllene, eucalyptol, dihydrocarvone, isomenthol, isomenthyl acetate, isopulegol, limonene (H315—Cat. 22, H317—Cat. 13), linalool (H317—Cat. 1)3, menthol, menthone, myosmine, piperitone, pulegone, tris(2-butoxyethyl) phosphate
5.	Other beverages–Energy	β-ionone, β-pinene, 1,3-di-tert-butylbenzene, benzaldehyde propylene glycol acetate, benzyl alcohol (H302—Cat. 41, H332—Cat. 44), carvone (H317—Cat. 1)3, ethyl maltol, isopulegol, menthol, methyl anthranilate, raspberry ketone, vanillin

Compounds are listed alphabetically along with its hazard statement codes according to the Classification, Labelling and Packaging (CLP) Regulation (EC) No 1272/2008, where applicable. The hazard statements and the applicable categories of toxicity for the specific flavors are explained in the legend. The flavor categories were taken from Krusemann et al. (2019) and identified according to the flavor descriptions listed on the respective packaging

¹H302 – Harmful if swallowed [Acute oral category 4 – Acute toxicity estimate (ATE*) between 300 and 2000 mg/kg bodyweight]

²H315 – Causes skin irritation [Skin irritation category 2 – production of reversible damage to skin following a 4 h skin exposure with 2 of 3 tested animals having a mean score between 2.3 and 4]

³H317 – May cause an allergic skin reaction [Skin sensitization Category 1 – when category 1A cannot be excluded but human data or animal data are not sufficient for a sub-categorization into category 1A or 1B

Skin sensitization Category 1B – low to moderate frequency occurrence in humans and/or from animal testing potential sensitization can be presumed]

⁴H332 – Harmful if inhaled [Acute inhalational category 4 – ATE between 10 and 20 mg/l]

*The ATE is derived from the LD50-values for the oral route and the LC50-values for the inhalational route

The underline is used for bettter visibility of compounds that have a CLP statement