Table 1.

Parameters used for computational modeling of AMPAR EPSCs in Control and Nrxn3 KO synapses

Default parameters used for simulation
Time step size31		0.5 µs
Cleft height32		15 nm
Vesicle fusion duration33,34		0.2 ms
GluA1 number32		134
Glutamate diffusion rate32		0.4 µm2/ms
Conductance35		31 pS
Distance between synapse and glial sheath31		40 nm
The radius of the release zone		36 nm
Glutamate per vesicle		3000
Transporter Density		2000/µm2
Parameters used in Fig. 3 (Based on STORM data)
	WT	Nrxn3 KO
Radius of SSD	0 ~ 34 nm	0 ~ 36 nm
No. of GluA1 in SSDa	41.6	31.2
The radius of the synapse (peri-SSD)	34 ~ 93 nm	36 ~ 83.5 nm
No. of GluA1 in the synapse (peri-SSD)a	58.4	54.8
Radius out of SSD	93 ~ 273 nm	83.5 ~ 196 nm
No. of GluA1 out of SSD	34	3

^aThe number of receptors does not need to be integers because the simulation can be regarded as an average of a series of simulation runs with integral receptor numbers.