Table 5.
CTCAE toxicity of tamoxifen with and without concomitant CBD.
| Tamoxifen-related side with tamoxifen only (N = 26) | Tamoxifen-related side effects with tamoxifen and CBD (N = 26) | |||
|---|---|---|---|---|
| N (%) | Grade 1 | Grade 2 | Grade 1 | Grade 2 |
| Insomnia | 16 (62%) | 10 (38%) | 19 (73%) | 3 (12%) |
| Hot flashes | 20 (77%) | 5 (19%) | 22 (85%) | 1 (4%) |
| Arthralgia | 15 (58%) | 10 (38%) | 21 (81%) | 3 (12%) |
| Mood alterations | 19 (73%) | 1 (4%) | 17 (65%) | 1 (4%) |
| Muscle cramp | 7 (27%) | 1 (4%) | 8 (31%) | – |
| Fatigue | 3 (12%) | 3 (12%) | 8 (31%) | 1 (4%) |
| Headache | 4 (15%) | – | 4 (15%) | – |
| Vaginal dryness | 2 (8%) | 1 (4%) | 1 (4%) | – |
| Amnesia | 4 (15%) | – | 2 (8%) | – |
| Weight gain | 2 (8%) | – | 1 (4%) | – |
| Dry mouth | – | – | 3 (12%) | |
| Nausea | 2 (8%) | |||
Toxicity is shown when it occurred in more than one patient.