Table 2.
Prognostic Factor Analysis for Overall Survival in CHB-HCC Patients
| Variables | Overall Survival | |||
|---|---|---|---|---|
| Univariate Analysis | Multivariate Analysis | |||
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Age (years) | 1.00 (0.98–1.02) | 0.903 | ||
| Gender (male) | 0.75 (0.48–1.19) | 0.219 | ||
| MAFLD | 0.29 (0.19–0.46) | 0.000 | 0.36 (0.22–0.57) | 0.000 |
| BMI | 0.89 (0.83–0.94) | 0.000 | 0.91 (0.86–0.97) | 0.006 |
| Type 2 diabetes | 0.80 (0.45–1.44) | 0.464 | ||
| Hypertension | 0.69 (0.43–1.10) | 0.118 | ||
| Liver cirrhosis | 0.79 (0.48–1.31) | 0.358 | ||
| ECOG PS (>0) | 2.01 (1.35–2.99) | 0.001 | 2.13 (1.40–3.24) | 0.000 |
| Alcohol | 1.32 (0.88–1.97) | 0.186 | ||
| AFP (>1000 ng/mL) | 1.77 (1.17–2.68) | 0.007 | 0.81 (0.50–1.32) | 0.398 |
| Child B and C | 2.60 (1.54–4.38) | 0.000 | 1.58 (0.87–2.88) | 0.133 |
| Histological grade | 0.041 | 0.193 | ||
| Well | (ref) | (ref) | ||
| Moderate | 2.43 (0.76–7.76) | 0.133 | 1.91 (0.46–7.94) | 0.372 |
| Poor | 3.77 (1.13–12.61) | 0.031 | 2.76 (0.63–12.00) | 0.177 |
| Tumor number (>1) | 1.42 (0.90–2.26) | 0.136 | ||
| Tumor size | 1.15 (1.09–1.21) | 0.000 | 1.06 (1.00–1.13) | 0.048 |
| Microvascular invasion | 3.95 (2.67–5.83) | 0.000 | 3.01 (1.96–4.64) | 0.000 |
| Metastases | 2.33 (1.27–4.25) | 0.006 | 0.96 (0.48–1.93) | 0.911 |
| Satellite nodules | 2.05 (1.26–3.35) | 0.004 | 1.19 (0.69–2.03) | 0.538 |
Note: p value of < 0.05 was considered statistically significant and shown in bold values.
Abbreviations: AFP, alpha fetoprotein; BMI, Body mass index; Child B and C, Child-Pugh class B and C; CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group performance status; HR, hazard ratio; HBsAg, Hepatitis B surface antigen; MAFLD, metabolic dysfunction-associated fatty liver disease.