Table 2.
Standardized multi-regression coefficients (β) as predictors of MoCA-J total score at follow-up
| Total n = 1186 | With HT&DL n = 553 | With HT n = 304 | With DL n = 178 | Without HT&DL n = 151 | ||
|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | Model 4 | Model 1 | ||
| HT & DL | Univariate coefficients | −0.05 | ||||
| Multi-regression coefficients (β) | 0.04 | |||||
| HT | Univariate coefficients | −0.11** | ||||
| Multi-regression coefficients (β) | −0.02 | |||||
| DL | Univariate coefficients | 0.02 | ||||
| Multi-regression coefficients (β) | 0.01 | |||||
| LDL | Univariate coefficients | 0.06* | −0.03 | 0.15** | 0.10 | 0.11 |
| Multi-regression coefficients (β) | 0.04 | 0.02 | 0.07 | 0.01 | 0.07 | |
| HDL | Univariate coefficients | 0.13*** | 0.14*** | 0.15** | 0.18* | 0.09 |
| Multi-regression coefficients (β) | 0.04 | 0.06* | 0.08 | 0.01 | 0.00 | |
| TG | Univariate coefficients | −0.01 | −0.02 | −0.02 | −0.08 | −0.05 |
| Multi-regression coefficients (β) | −0.01 | −0.03 | −0.05 | 0.04 | 0.00 | |
| SBP | Univariate coefficients | −0.05 | −0.05 | 0.09 | −0.05 | −0.03 |
| Multi-regression coefficients (β) | 0.04 | 0.01 | 0.10* | 0.03 | 0.03 | |
| DBP | Univariate coefficients | 0.06* | 0.11* | 0.12* | 0.08 | −0.02 |
| Multi-regression coefficients (β) | 0.04 | 0.08* | 0.00 | 0.03 | 0.03 |
The covariates of model 1 include age, sex, diabetes, BMI, smoking and drinking history, and the MoCA-J total score at the baseline
The covariates of model 2 include model 1 + anti-hypertensive treatment and anti-dyslipidemia treatment
The covariates of model 3 include model 1 + anti-hypertensive treatment
The covariates of model 4 include model 1 + anti-dyslipidemia treatment
Parameter estimates (β) can be interpreted as differences in MoCA-J total scores for each 1 mg dL increase in LDL, HDL, and TG, and 1 mmHg increase in SBP and DBP
HT hypertension, DL dyslipidemia, LDL-C low-density lipoprotein-cholesterol, HDL-C high-density lipoprotein-cholesterol, TG triglycerides, SBP systolic blood pressure, DBP diastolic blood pressure, MoCA-J the Japanese version of Montreal Cognitive Assessment
*P < 0.05, **P < 0.01, ***P < 0.001