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. 2023 Apr 25;47(4):500–513. doi: 10.4093/dmj.2022.0110

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Copyright © 2023 Korean Diabetes Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — Curcumin 2005-8 (Cur5-8) reduces lipid accumulation in hepatocytes. (A, B, C) Cell morphology and BODIPY staining were observed under a microscope following 24 hours of oleic acid (OA) treatment. In alpha mouse liver 12 (AML12) cells, OA was combined with Cur, Cur5-8, and EW-7197. (D, E) Levels of adipose differentiation-related protein (ADRP), sterol regulatory element-binding protein 1c (Srebp1c), and fatty acid synthase (Fas) were measured using a Western blotting assay. ^aP<0.001 vs. control (Con), ^bP<0.001 vs. oleic acid, ^cP<0.001 vs. oleic acid+Cur5-8, ^dP<0.05 vs. Con, ^eP<0.05 vs. oleic acid.