Fig. 6.

Curcumin 2005-8 (Cur5-8) and EW ameliorate liver fibrosis. (A, B, C) Liver fibrosis was measured using Sirius red and trichrome staining. The degree of liver fibrosis in the experimental groups was compared by quantifying the positively-stained area. (D, E) Levels of extracellular matrix-related α-smooth muscle actin (α-SMA), collagen I (ColI), fibronectin, and transforming growth factor β (TGF-β) canonical pathway-related p-SMAD2/3 were measured. ^aP<0.05 vs. control (Con), ^bP<0.05 vs. methionine-choline-deficient diet (MCD), ^cP<0.001 vs. Con, ^dP<0.001 vs. MCD.