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. 2023 Jun 8;22(8):100591. doi: 10.1016/j.mcpro.2023.100591

Table 1.

The human proteome in UniProtKB

Sequence set No of sequences (2023_02) Website query Download
Canonical sequences 20,407 proteome:up000005640 AND reviewed:true Website - FASTA (Canonical),
Tab-separated, XML. RDF/XML,Text, GFF, JSON
aEntries containing additional reviewed isoforms 10,647 proteome:up000005640 AND (cc_ap:∗) (identifies entries containing reviewed isoforms) Website - FASTA (Canonical + isoforms)
Number of reviewed isoforms 22,095 www.uniprot.org/help/downloads - FASTA
Additional unreviewed isoforms 62,085 proteome:up000005640 AND reviewed:false Website - FASTA Tab-separated, XML. RDF/XML,Text, GFF
Complete proteome (Reviewed entries + unreviewed isoforms) 82,492 proteome:up000005640 Website - FASTA Tab-separated, XML. RDF/XML,Text, GFF
Total proteome (Canonical sequences + reviewed isoforms + unreviewed isoforms) 104,587 proteome:up000005640 Website - FASTA (download FASTA (canonical + isoform))
Additional UniProtKB/TrEMBL entries 125,361 (taxonomy_id:9606) AND (reviewed:false) NOT (proteome:up000005640) Website - FASTA Tab-separated, XML. RDF/XML,Text, GFF
a

Query gives entries containing reviewed isoforms, not individual entries for each isoform.