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. 2023 Jun 9;16(3):451–472. doi: 10.1016/j.jcmgh.2023.06.003

Figure 4.

Figure 4

Abnormal hepatic differentiation in DKC1-mutant cultures. (A) qRT-PCR analysis of hepatic transcription factors, hepatic marker genes, MYC, and MYC target genes (n = 4). ∗P < .05, ∗∗P < .01. Error bars indicate means ± SD. (B) HNF4α and Ki67 staining of mutant HBs and corrected HBs. Scale bar: 100 μm. (C) HNF4α and Ki67 staining of mutant HEPs and corrected HEPs. Scale bar: 100 μm. (D) Immunostaining of HNF4α and FABP1 in mutant HEPs and corrected HEPs. Scale bar: 100 μm. (E) Expression of cytokines in HEPs analyzed by qRT-PCR and enzyme-linked immunosorbent assay (n = 4). ∗∗P < .01. Error bars indicate means ± SD. Cor, corrected; Mut, mutant.