Figure 6.

Single-cell transcriptomics in hepatostellate organoids. (A–C) Uniform Manifold Approximation Projection or Dimensional Reduction (UMAP) of 2991 single-cell transcriptomes from the 4 admixed hepatostellate organoid cultures, annotated by (A) replicate, (B) cell type, and (C) organoid genotype. (D) UMAPs showing expression of the indicated marker genes for each cell type. (E and F) Cell cycle phase analysis in hepatocyte clusters and stellate cell clusters. (G) Quantification of cell cycle distribution in hepatostellate organoids, and more specifically in hepatocyte and stellate cell clusters, as indicated. Cor, corrected; Mut, mutant.