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. 2023 Jun 9;16(3):451–472. doi: 10.1016/j.jcmgh.2023.06.003

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Single-cell transcriptomics of hepatostellate organoids reveals that DCK1-mutant hepatocytes elicit pathologic responses in stellate cells. UMAP projections for HEPs annotated by (A) cluster or (B) organoid genotype. UMAP projections for stellate cells (HSCs) annotated by (C) cluster or (D) organoid genotype. (E) The fraction of cells within each of the 3 HEP and HSC clusters by organoid genotype. (F) Violin plots showing expression of hepatocyte marker genes and MYC across 3 HEP clusters. (G) Expression of activated stellate cell marker genes across 3 HSC clusters. (H) GSEA of HEP I vs HEP II and HEP I vs HEP III. (I) GSEA of HSC I vs HSC II and HSC I vs HSC III. Cor, corrected; Mut, mutant.