Table 4.
Relationship between major amino-acid substitutions in spike receptor binding domain (RBD) and hospital mortality in univariable Cox proportional hazard regression analysis
| Non synonymous mutations in Spike RBD | Na | HR 95% CI | P value |
|---|---|---|---|
| R346T/I | 34 | 1.10 [0.47; 2.57] | 0.821 |
| K444T/R | 29 | 1.29 [0.62; 3.38] | 0.389 |
| L452R | 81 | 1.33 [0.49; 3.56] | 0.575 |
| N460K | 28 | 1.49 [0.64; 3.48] | 0.353 |
| F486V | 81 | 1.33 [0.49; 3.56] | 0.575 |
HR 95% CI: Hazard ratio 95% Confidence Interval; aNumber of patients with the mutation on a total of 108 patient-related samples for which full-length viral genome sequence analysis yielding high coverage with > 95% on spike gene was performed