Fig. 1.

Chronic constriction injury results in neuropathic pain and cognitive decline in mice. a Flowchart of this experiment. b, c The comparison results of PWT and PWL between the CCI group and sham group. d–f The comparison results of the number of arm entries and the positive spontaneous alternation rate between the sham and CCI groups in the Y-maze test. g–i The comparison results of the investigation time of objects and the discrimination index between the sham and CCI groups in the NOR test. j–l Comparison of the spending time of the targeted zone and the number of platform crossings between the sham and CCI groups in the MWM test. CCI chronic constriction injury, OFT open-field test, PWL paw withdrawal latency, PWT paw withdrawal threshold, MWM Morris water maze, NOR novel object recognition. Data are presented as the mean ± SEM (n = 6 per group). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001