Fig. 5.

TLR3 KO improves the impairment of dendritic spines in the hippocampus induced by chronic neuropathic pain in mice. a The protein levels of PSD95 and SYN in the hippocampus on day 21 after sham surgery and CCI. b The results of spine numbers in branches and shafts in CA1 pyramidal neurons on day 21 after sham surgery and CCI. Scale bar = 100 μm. c The total dendritic length, total intersection numbers, apical intersection numbers and basal intersection numbers on day 21 after sham surgery or CCI. Scale bar = 50 μm. Data are presented as the mean ± SEM (n = 6 per group). ^*, WT-Sham vs. WT-CCI; ^#, WT-CCI vs. KO-CCI. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001; ^#P < 0.05, ^###P < 0.001