Table III.
Results of the diagnostic work-up
| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Case 6 | Case 7 | Case 8 | |
|---|---|---|---|---|---|---|---|---|
| Chimerism in peripheral blood (CD3) | 100% (Day 31) | 0% (Day 37) | 10% (Day 45) | 93%(Day 87) | 69% (Day 188) 87% (Day 199) 89% (Day 206) 81% (Day 223) 46% (Day 245) |
78% (Day 25) 87% (Day 33) |
13% (Day 51) | 8% (Day 46), 14% (Day 60) 91% (Day 63) 86% (Day 69) 65% (Day 74) 64% (Day 77) 67% (Day 88) 60% (Day 95) 53% (Day 102) 53% (Day 109) 47% (Day 116) 100% (Day 158) |
| Chimerism in whole blood | 93% | 0% | 21% | 78% | 0% | 26% | 0% | NA |
| Chimerism in bone marrow | 94% | 0% | 27% | 25% | 0% | 10% | 0% | 6% |
| Bone marrow (BM) biopsy | Hypocellular BM, trilineage hypoplasia | NA | Hypocellular BM (10%), granulocytic and erythropoietic hypoplasia | Variably cellular bone marrow (35%), granulocyte hypoplasia | Negative | Hypocellular BM (5%), trilineage hypoplasia | NA | Hypocellular BM (<10%), trilineage hypoplasia |
| FISH analysis | Positive on skin biopsy, scoring % cells with XX pattern: 15% | Positive on skin biopsy, scoring % cells with XY pattern: 37% | Positive on skin biopsy, scoring % cells with XX pattern: 30% | |||||
| Grade of GVHD | Grade 1-Skin, Grade 1-Intestinal |
Grade 1-Skin | Grade 4-Skin, Grade 3-Intestinal | Grade 2-Skin | Grade 1-Skin | Grade 1-Skin | Grade 2-Skin | Grade1-Skin, Grade 0-Upper GI, Grade1-Lower GI |