Table 1.
Amnestic AD (n=15) | Non-amnestic AD (n=19) | Controls (n=14) | Amnestic vs controls | Non-amnestic vs controls | Amnestic vs non-amnestic | |
---|---|---|---|---|---|---|
Age at onset (years) | 56.1 ± 9.0 | 55.7 ± 7.5 | N/A | N/A | N/A | ns |
Age at EEG (years) | 60.6 ± 9.7 | 60.5 ± 6.7 | 64.5 ± 5.6 | * | ns | ns |
Disease duration (years) | 5.1 ± 2.4 | 5.3 ± 1.9 | N/A | N/A | N/A | ns |
Female (%) | 64.3 | 57.9 | 64.3 | ns | ns | ns |
Education (years) | 15.9 ± 2.5 | 16.5 ± 2.8 | 17.4 ± 1.9 | ns | ns | ns |
CDR at EEG time (%) | 0.86 ± 0.4 | 0.84 ± 0.4 | 0 ± 0 | ** | ** | ns |
Normal | 0 | 0 | 100 | N/A | N/A | N/A |
MCI | 43 | 36.9 | 0 | N/A | N/A | N/A |
Mild dementia | 50 | 57.9 | 0 | N/A | N/A | N/A |
Moderate dementia | 7 | 5.2 | 0 | N/A | N/A | N/A |
CDR SoB at EEG time | 5.4 ± 2.3 | 4.6 ± 2.3 | 0 ± 0 | ** | ** | ns |
MMSE at EEG time | 21.1 ± 5.7 | 22. ± 4.5 | 29.5 ± 0.8 | ** | ** | ns |
Anticholinesterase Inhibitors (%) | 80 | 89.5 | 0 | ** | ** | ns |
SSRI Antidepressants (%) | 46.7 | 42.1 | 7.1 | * | * | ns |
Epileptiform activity (%) | 20 | 26.3 | 0 | P=0.07 | * | ns |
Data are shown as mean ± SD
Significance
P<0.05
P<0.01
ns, non-significant; N/A, not applicable
Abbreviations: CDR, Clinical Dementia rating; CDR-SoB, CDR Sum of Boxes; MMSE, Mini Mental State Examination; SSRI, Selective serotonin reuptake inhibitors