Table 2.
Frequencies of HLA alleles in patients with LEV-SCARs and population controls
| HLA genotype | Carrier, No. (%) |
P | Pca | Odd ratio (95% CI) | |
|---|---|---|---|---|---|
| LEV-SCAR patients, (n = 11) | Population controls, (n = 806) | ||||
| A∗30:01 | 5 (45.5) | 132 (16.4) | 0.024 | 0.12 | 4.26 (1.28–14.15) |
| B∗13:01 | 4 (36.4) | 58 (7.2) | 6.63 × 10−3 | 0.027 | 7.37 (2.1–25.91) |
| B∗13:02 | 6 (54.5) | 146 (18.1) | 7.68 × 10−3 | 0.031 | 5.42 (1.63–18.02) |
| B∗15:02 | 2 (18.2) | 32 (4) | 0.073 | 0.29 | 5.38 (1.12–25.9) |
| C∗03:04 | 5 (45.5) | 122 (15.1) | 0.018 | 0.071 | 4.67 (1.4–15.55) |
| C∗06:02 | 6 (54.5) | 205 (25.4) | 0.039 | 0.16 | 3.52 (1.06–11.65) |
| DQA1∗02:01 | 6 (54.5) | 198 (24.6) | 0.033 | 0.13 | 3.68 (1.11–12.2) |
| DQA1∗06:01 | 5 (45.5) | 105 (13) | 0.01 | 0.038 | 5.56 (1.67–18.55) |
| DQB1∗02:02 | 6 (54.5) | 168 (20.8) | 0.015 | 0.061 | 4.56 (1.37–15.11) |
| DQB1∗03:01 | 8 (72.7) | 290 (36) | 0.022 | 0.088 | 4.74 (1.25–18.02) |
| DRB1∗07:01 | 6 (54.5) | 198 (24.6) | 0.033 | 0.13 | 3.68 (1.11–12.2) |
| DRB1∗12:02 | 5 (45.5) | 99 (12.3) | 7.48 × 10−3 | 0.03 | 5.95 (1.78–19.86) |
| Serotype B13 | 10 (90.9) | 197 (24.4) | 7.91 × 10−6 | 30.91 (3.93–243.01) | |
Abbreviations: CI, confidence interval; LEV-SCARs, levofloxacin-induced severe cutaneous adverse drug reactions; OR, odds ratio.
a
p values corrected with the Bonferroni correction for multiple comparisons (five for HLA-A, four for HLA-B, -C, DQA1, DQB1 and DRB1). Bold entries indicate that Pc < 0.05.