Table 3.
Frequencies of HLA alleles in patients with LEV-SCARs and LEV-tolerant controls
| HLA genotype | Carrier, No. (%) |
P | Odd ratio (95% CI) | |
|---|---|---|---|---|
| LEV-SCAR patients, (n = 12) | Tolerant controls, (n = 100) | |||
| B∗13:01 | 4 (33.3) | 10 (10.0) | 0.043 | 4.5 (1.15–17.65) |
| B∗13:02 | 6 (50.0) | 14 (14.0) | 7.21 × 10−3 | 6.14 (1.73–21.76) |
| Serotype B13 | 10 (83.3) | 22 (22.0) | 4.85 × 10−5 | 17.73 (3.61–86.95) |
Abbreviations: CI, confidence interval; LEV, levofloxacin; LEV-SCARs, levofloxacin-induced severe cutaneous adverse drug reactions; OR, odds ratio.