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. 2023 Jul 24;14:1238503. doi: 10.3389/fphar.2023.1238503

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Copyright © 2023 Gómez-Herrera, Patlán, Estrada-Garrido, Hernández-Cruz and Luis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BL-1249 hyperpolarizes the resting membrane potential of HEK-Kv10.1 cells. (A,B) Current-clamp recording of RMP of HEK-Kv10.1 cells in the presence of DMSO and BL (100 µM), respectively. (C,D) Effects on the RMP of HEK-Kv10.1 cells recorded in the presence of DMSO (n = 4) and BL (n = 7), respectively. (E,F) Average effect of DMSO and BL on the RMP of HEK-Kv10.1 cells. Above, data represent the shift of RMP in each cell concerning the control condition (dotted line) obtained before applying every compound. Below is a summary histogram of the average change of the RMP.