TABLE 4.

Top 20 ADRs of anti-TNFα drugs.

Adalimumab (N = 591705)		Infliximab (N = 172961)		Etanercept (N = 542647)		Golimumab (N = 38629)		Certolizumab pegol (N = 57331)
ADR	Report rate %	ADR	Report rate %	ADR	Report rate %	ADR	Report rate %	ADR	Report rate %
Arthralgia	5.07	Infusion-related reaction	6.05	Arthralgia	5.52	Lower respiratory tract infection	3.44	Rash	3.57
Headache	3.56	Dyspnea	4.71	Rheumatoid arthritis	4.11	Rheumatoid arthritis	3.17	Arthralgia	3.44
Psoriasis	3.33	Crohn’s disease	4.07	Psoriasis	3.96	Pneumonia	3.09	Rheumatoid arthritis	3.28
Nasopharyngitis	3.12	Pneumonia	3.75	Pain in extremity	3.53	Arthralgia	2.71	Crohn’s disease	3.04
Nausea	3.01	Arthralgia	3.09	Headache	3.36	Nasopharyngitis	2.54	Nausea	2.90
Diarrhea	2.76	Abdominal pain	2.87	Nasopharyngitis	2.98	Infection	2.35	Headache	2.87
Rash	2.58	Nausea	2.85	Sinusitis	2.26	Rash	1.99	Diarrhea	2.84
Crohn’s disease	2.58	Rash	2.51	Nausea	2.14	Headache	1.82	Nasopharyngitis	2.80
Pain in extremity	2.56	Pruritus	2.32	Cough	2.10	Urinary tract infection	1.61	Infection	2.71
Rheumatoid arthritis	2.05	Headache	2.23	Joint swelling	1.88	Nausea	1.58	Pneumonia	2.50
Abdominal pain	1.90	Diarrhea	2.14	Pneumonia	1.85	Influenza	1.44	Psoriasis	2.15
Pneumonia	1.87	Flushing	2.05	Rash	1.76	Colitis ulcerative	1.41	Abdominal pain	2.10
Pruritus	1.86	Vomiting	1.97	Lower respiratory tract infection	1.62	Psoriasis	1.40	Urinary tract infection	1.96
Cough	1.79	Hypersensitivity	1.90	Pruritus	1.62	Diarrhea	1.34	Pruritus	1.86
Infection	1.71	Urticaria	1.89	Infection	1.58	Alopecia	1.18	Sinusitis	1.72
Dizziness	1.71	Colitis ulcerative	1.80	Back pain	1.48	Pain in extremity	1.15	Lower respiratory tract infection	1.68
Dyspnea	1.56	Erythema	1.73	Diarrhea	1.39	Pruritus	1.14	Dizziness	1.61
Vomiting	1.56	Psoriasis	1.58	Dizziness	1.38	Dyspnea	1.05	Influenza	1.44
Back pain	1.55	Dizziness	1.34	Musculoskeletal stiffness	1.35	Dizziness	1.02	Dyspnea	1.42
Sinusitis	1.51	Cough	1.24	Influenza	1.23	Joint swelling	0.99	Pain in extremity	1.41