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Modification sites and structure of CAD and PRPS1. (A) PRPS1 is phosphorylated by the kinases CDK1, AMPK and KHK-A to regulate its activity in cells. CDK1 and KHK-A mediated PRPS1 phosphorylation promotes its activity, and AMPK mediated PRPS1 phosphorylation inhibits its activity. (B) CAD is phosphorylated by the kinases MAPK, S6K1 and PKC to promote its activity in cells.
