Table 1.
Enzymes of de novo nucleotide biosynthetic pathway overactivated in cancers.
| Gene | Protein | Cancer |
|---|---|---|
| PRPS1/2 | Phosphoribosyl Pyrophosphate Synthetase |
Acute myeloid leukemia Colorectal cancer Burkitt's lymphoma |
| GMPS | GMP synthetase | Esophageal squamous cell carcinoma |
| PPAT | phosphoribosyl pyrophosphate amidotransferase |
Lung cancer |
| CAD | Carbamoyl-Phosphate Synthetase 2 Aspartate Transcarbamylase Dihydroorotase |
Liver cancer Triple-negative breast cancer Glioblastoma |
| DHODH | Dihydroorotate Dehydrogenase | Liver cancer |
| HK-II | Hexokinase | Gallbladder cancer |
| TKT | Transketolase | multiple cancers |
| RPIA | Ribose-5-phosphate isomerase-A | Colorectal cancer |
| MTHFD2 | Methylene-THF dehydrogenase/cyclohydrolase | Breast cancer |