Table 2.

Roles of CARM1 in cell differentiation and development.

Process	Substrate	Methylated arginine residues	Effects of arginine methylation	References
Early embryonic development	Histone H3	R17, R26	Transcriptional activation	53,54,55,56,57,63,65
	BAF155	Not determined	Decreased stability of the SWI/SNF complex	66
T cells development and Hematopoiesis	Not determined	–	Proper cellularity and survival of hematopoietic progenitor cells	49,50
Lung morphogenesis	Not determined	–	Proper expression of Aqp1, Aqp5, Gadd45g, Scn3b, and Nkd1	52
Skeletal muscle differentiation	Pax7	R10, R13, R22, R37	Activation of Myf5 expression	59
	Histone H3	R17	Activation of the expression of late myogenic genes and myogenic microRNAs	75,76
Spermiogenesis	p300	R2142	Impaired formation of p300-ACT-CREMτ complex	60