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Succinate and succinylation in immunity. (A) The scheme of the TCA cycle. (B) Succinate and succinylation play multi-faceted roles in the tumor microenvironment including macrophage (TAM, tumor-associated macrophage) polarization, T cell growth and differentiation, dendritic cell antigen processing capacity, follicular B cell activation and B cell antibody response, and tumor metastasis.
