Table 1.
The role of lysine succinylation in cancer.
| Tissue/cell | Targets | Function | Content | Reference |
|---|---|---|---|---|
| Gastric cancer tissue | CPT1A | Increase the K47 succinylation of S100A10 | Increase gastric cancer invasion | 40 |
| Gastric cancer tissue | CPT1A | Succinylate lactate dehydrogenase on K222 | Promote the invasion and proliferation of gastric cancer | 41 |
| ESCC cell | DMS | Increase the level of lysine succinylation | Inhibit the cell growth and migration of esophageal squamous cell carcinoma | 42 |
| Breast cancer tissue | SIRT5 | Inhibit the succinylation of metabolic enzymes | Promote breast cancer proliferation | 43 |
| Breast cancer tissue | H2A.X complexes | Associated with the DNA damage response | Affect DNA damage repair by regulating the formation of protein foci | 39 |