Table 2.

Main physiological functions of genes containing LXRE and CRE sites.

Gene	Function	References
ABCA1	Cholesterol efflux	63,64
ABCG1	Cholesterol efflux	65,66
ACC	Fatty acid synthesis	58
ACSL3	Fatty acid metabolism	67
Angptl3	Triglyceride metabolism	68
AKR1C4	Bile acid biosynthesis, steroid and hormone metabolism	69
Arl7	Cholesterol efflux	70
α-TTP	Vitamin E regulatory protein	71
CETP	Cholesterol metabolism and transportation	72
CH25H	25-Hydroxycholesterol synthesis	73
CYP7A1	Conversion of cholesterol to bile acids	74
FABP4	Fatty acid metabolism and adipocyte differentiation	75
FAS	Fatty acid synthesis	59,60
I-BABP	Enterohepatic circulation of bile acids	75
IFN-γ	Immune and inflammatory responses	26,27
IL-1β	Immune and inflammatory responses	28
IL-4	Immune and inflammatory responses	29
IL-6	Immune and inflammatory responses	30
IL-8	Immune and inflammatory responses	31
IL-10	Immune and inflammatory responses	32
IL-17	Immune and inflammatory responses	34,35
LPCAT3	Phospholipid metabolism	76
LPL	Hydrolysis of circulating triglyceride-rich lipoproteins	77
MIG12	Fatty acid synthesis and TG accumulation	78
Ostalpha/beta	Bile acid absorption	79
PLTP	Phospholipid metabolism	80
PPARγ	Lipid metabolism	91
SCD-1	Monounsaturated fatty acid synthesis	62
sPLA2	Phospholipid metabolism	81
SR-BI	Cholesterol uptake and efflux	82
SREBP-1c	Lipid synthesis	13,90
Sult1e1	Sulfation and inactivation of estrogen	83
TNFα	Immune and inflammatory responses	33
UGT1A3	Bile acid glucuronidation	84
VEGF	Angiogenesis	106