Table 1.
The information of common BETi and BET-PROTAC.
| Compound | Classification | Molecular weight | Formula/E3 ubiquitin ligase recognition motif | PubChem Compound ID number |
|---|---|---|---|---|
| JQ1 | BETi | 400.88 | C₁₉H₁₇ClN₄O₂S | 46,907,787 |
| I-BET151 | BETi | 415.44 | C₂₃H₂₁N₅O₃ | 52,912,189 |
| I-BET762 | BETi | 396.83 | C₂₀H₁₇ClN₄O₃ | 46,943,432 |
| OTX015 | BETi | 383.42 | C₁₈H₁₇N₅O₃S | 9,936,746 |
| PLX51107 | BETi | 438.48 | C₂₆H₂₂N₄O₃ | 90,448,953 |
| RO6870810 | BETi | 540.13 | C27H34ClN7OS | 54,670,351 |
| Mivebresib, ABBV-075 | BETi | 459.47 | C₂₂H₁₉F₂N₃O₄S | 71,600,087 |
| GS-5829 | BETi | 437.49 | C₂₆H₂₃N₅O₂ | 86,281,210 |
| ABBV-744 | BETi | 491.55 | C₂₈H₃₀FN₃O₄ | 132,010,322 |
| ARV-771 | BET-PROTAC | 986.64 | VHL ligand | 126,619,980 |
| dBET1 | BET-PROTAC | 785.3 | Thalidomide | 91,799,313 |
| ARV-825 | BET-PROTAC | 923.43 | Thalidomide | 92,044,400 |