Table 2.
Functions and mechanisms of butyrylation in diseases.
| Disease | Cell | Function | Animal | Reference |
|---|---|---|---|---|
| Type 1 Diabetes | HEK 293T | Upregulate several genes associated with diabetes and so on | NA | 69 |
| Type 2 Diabetes | Primary hepatocytes | Increase H3K36me2 in DIO mice and change butyrylation in DIO | A high-fat diet-induced obese mice | 66 |
| Cardiac hypertrophy | Hap1 and neonatal cardiac myocytes | Reduced H3K9bu levels under an HFD and stress are detrimental to cardiovascular health | Transverse aortic constriction (TAC) in mice | 49 |
| Male epigenome features | Mouse spermatogenic cells | The interchangeable use of two closely related histone acylation marks at H4K5 | NA | 48 |
| Bladder cancer | The human epithelial bladder cancer cell line 5637 | The mechanism by which butyrylation is mediated is not well defined | NA | 70 |