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The important role of ferroptosis in RCC. As a crucial form of RCC cell death, ferroptosis can suppress tumor progression. RCC cells are susceptible to iron overload and dysfunction in amino acid and lipid metabolism, which leads to abnormal ferroptosis and ultimately leads to tumor progression and unfavorable prognosis. Ferroptosis is also regulated by various genes, proteins and ncRNAs, which may provide potential clinical biomarkers and therapeutic targets for this disease.
