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. 2023 Jul 13;26(8):107376. doi: 10.1016/j.isci.2023.107376

Figure 6.

Figure 6

STING reprograms TAMs to be tumoricidal

(A) RAW264.7 cells were induced to TAM by tumor cell conditioned medium. Tumor cells (MC38 or CT26) and TAM were then labeled with fluorescence, and the number of tumor cells was counted after co-culture for 48 h.

(B) With or without DMXAA, RAW264.7 cells were induced to TAM using tumor cell-conditioned media. MC38 cells were co-cultured with TAM and qPCR was done for the analysis of the mRNA levels of markers of TAM in RAW264.7.

(C) WT or STING, bone marrow macrophages, were induced to TAM using tumor cell-conditioned media. Tumor cells (MC38 or CT26) and TAM were labeled with fluorescence, and the number of tumor cells was counted after co-culture for 48 h.