Table 2.

Comparation among different T cell sources.

T cell subset	Frequency in human peripheral blood T cells	MHC restriction	Advantages	Disadvantages
αβT	90%-95%	YES	Highly abundance; well-established system for clinical application	GvHD and host rejection; the need for multiple manipulations
iNKT	0.01%-1%	NO	Double killing effects; lack of GvHD; better tumor localization	Low frequency; host rejection
γδT	5%-10%	NO	Multiple mechanisms of action; lack of GvHD; better migration and infiltration; antigen cross-presentation	Low frequency; host rejection
DNT	1%-3%	NO	Multiple targeting; lack of GvHD and host rejection	Low frequency
MAIT	1%-10%	NO	Multiple mechanisms of action; lack of GvHD; effector memory-like phenotype	Low frequency; host rejection; immature expansion system