TABLE 1.
Conservation of the PY motif within the matrix proteins of various rhabdoviruses and filoviruses
| Virus | Protein sequencea | Positionb | GenBank accession no. |
|---|---|---|---|
| VSV (Indiana) | KLGIA PPPY EEDTS | 24–27 | X04452 |
| VSV (New Jersey) | KKMGL PPPY DESCP | 24–27 | M14553 |
| Rabies virusc | DLWLP PPEY VPLKE | 35–38 | M31046 |
| Piry virus | MEWES PPSY NEIKS | 33–36 | D26175 |
| Spring viremia of carp virus | KSKGT PPTY EETLA | 17–20 | K02123 |
| Ebola virus (Zaire strain) | ILPTA PPEY MEAIY | 10–13 | L11365 |
| Marburg virus (Popp strain) | MQYLN PPPY ADHGA | 16–19 | Z29337 |
a
The sequences are derived from the matrix (M) proteins of VSV, rabies virus, Piry virus, and spring viremia of carp virus and from the VP40 proteins of Ebola and Marburg viruses.
b
The numbers correspond to amino acid positions of the PY motif within the protein beginning from the N terminus.
c
This sequence (14 amino acids) of the rabies virus M protein is perfectly conserved in the strains SAD B19, CVS, Nishigahara, ERA, and PV.