Table 1.
Prevalent cases, deaths, and disability-adjusted life years (DALYs) for CAVD disease in 2019, and net drift in age standardized rates (ASRs) per 100, 000, by Global Burden of Disease region, from 1990 to 2019
| Prevalence | DALYs | Deaths | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Regions | No, in thousands (95% UI), 2019 | All-age rate per 100 000 (95% UI), 2019 | ASRs per 100 000 (95% UI), 2019 | Net drift (95% CI), % | No, in thousands (95% UI), 2019 | All-age rate per 100 000 (95% UI), 2019 | ASRs per 100 000 (95% UI), 2019 | Net drift (95% CI), % | No, in thousands (95% UI), 2019 | All-age rate per 100 000 (95% UI), 2019 | ASRs per 100 000 (95% UI), 2019 | Net drift (95% CI), % |
| Global | 9404.08 (8079.6, 10 889.73) | 121.54 (104.42, 140.74) | 116.34 (100.39, 134.5) | 3.69 (3.52, 3.87) | 1837.75 (1637.02, 2031.85) | 23.75 (21.16, 26.26) | 23.90 (21.10, 26.55) | −0.70 (−0.76, −0.64) | 126.83 (105.6, 141.39) | 1.64 (1.36, 1.83) | 1.76 (1.45, 1.97) | −0.83 (−0.91, −0.74) |
| High-income Asia Pacific | 1715.7 (1450.88, 2042.13) | 916.06 (774.67, 1090.35) | 408.4 (348.93, 479.89) | 1.66 (1.57, 1.75) | 142.13 (109.60, 165.94) | 75.89 (58.52, 88.6) | 24.46 (19.89, 28.22) | −2.10 (−2.22, −1.98) | 13.57 (9.08, 16.51) | 7.25 (4.85, 8.81) | 1.98 (1.40, 2.36) | −2.51 (−2.76, −2.26) |
| High-income North America | 1492.89 (1305.2, 1727.5) | 409.50 (358.02, 473.86) | 244.39 (214.46, 279.6) | 1.07 (0.93, 1.21) | 314.81 (274.62, 346.35) | 86.35 (75.33, 95.01) | 46.80 (41.53, 51.25) | −1.58 (−1.69, −1.48) | 27.19 (22.16, 30.24) | 7.46 (6.08, 8.29) | 3.64 (3.02, 4.02) | −1.62 (−1.78, −1.46) |
| Western Europe | 1862.79 (1577.56, 2209.09) | 426.94 (361.57, 506.31) | 204.84 (174.62, 240.59) | 6.58 (6.33, 6.82) | 543.78 (471.46, 598.09) | 124.63 (108.06, 137.08) | 51.94 (45.69, 56.95) | −0.83 (−0.96, −0.70) | 47.89 (39.52, 53.66) | 10.98 (9.06, 12.3) | 4.05 (3.40, 4.51) | −0.95 (−1.17, −0.72) |
| Australasia | 320.82 (272.23, 381.06) | 1103.86 (936.68, 1311.11) | 649.5 (552, 772.74) | 10.12 (9.85, 10.38) | 23.97 (20.44, 27.5) | 82.49 (70.34, 94.62) | 44.54 (38.48, 51.02) | −1.12 (−1.29, −0.96) | 1.87 (1.51, 2.11) | 6.42 (5.21, 7.25) | 3.18 (2.62, 3.58) | −1.66 (−2.16, −1.16) |
| Andean Latin America | 33.35 (28.25, 39.02) | 52.44 (44.42, 61.35) | 59.04 (50.07, 69.05) | 8.76 (8.37, 9.16) | 7.26 (5.88, 8.87) | 11.42 (9.24, 13.95) | 12.54 (10.21, 15.28) | −0.11 (−0.35, 0.13) | 0.29 (0.24, 0.35) | 0.46 (0.37, 0.56) | 0.53 (0.43, 0.64) | −0.33 (−1.16, 0.50) |
| Tropical Latin America | 58.6 (47.23, 72.05) | 26.21 (21.12, 32.23) | 23.73 (19.16, 29.01) | 3.67 (3.44, 3.90) | 70.73 (63.57, 80.92) | 31.63 (28.43, 36.19) | 29.50 (26.5, 33.74) | −0.64 (−0.74, −0.54) | 3.58 (3.11, 4.14) | 1.60 (1.39, 1.85) | 1.56 (1.34, 1.80) | −0.65 (−0.88, −0.42) |
| Central Latin America | 76.96 (63.86, 91.38) | 30.78 (25.54, 36.55) | 31.82 (26.45, 37.75) | 6.55 (6.29, 6.81) | 44.87 (36.84, 55.56) | 17.95 (14.74, 22.22) | 18.72 (15.40, 23.13) | 0.22 (0.11, 0.32) | 1.96 (1.61, 2.43) | 0.78 (0.64, 0.97) | 0.85 (0.70, 1.06) | 0.14 (−0.20, 0.49) |
| Southern Latin America | 101.89 (87.12, 120.8) | 152.64 (130.52, 180.96) | 122.72 (104.78, 145.67) | 7.39 (7.23, 7.55) | 42.48 (38.29, 46.44) | 63.64 (57.36, 69.57) | 50.54 (45.69, 55.27) | −0.41 (−0.49, −0.33) | 2.84 (2.46, 3.16) | 4.26 (3.68, 4.73) | 3.3 (2.85, 3.66) | −0.49 (−0.78, −0.20) |
| Caribbean | 45.47 (37.69, 54.85) | 96.40 (79.92, 116.29) | 87.51 (72.62, 105.56) | 7.32 (6.95, 7.70) | 11.32 (9.16, 14.16) | 24.01 (19.42, 30.01) | 22.09 (17.87, 27.65) | 0.22 (0.07, 0.37) | 0.52 (0.42, 0.63) | 1.09 (0.89, 1.33) | 1.00 (0.82, 1.22) | 0.08 (−0.49, 0.65) |
| Central Europe | 1260.56 (1067.65, 1479.62) | 1103.59 (934.7, 1295.37) | 608.31 (517.94, 713.51) | 6.96 (6.72, 7.21) | 84.11 (69.74, 99.02) | 73.63 (61.06, 86.69) | 39.15 (32.37, 46.15) | 4.11 (3.91, 4.31) | 4.68 (3.77, 5.58) | 4.09 (3.30, 4.89) | 2.08 (1.68, 2.49) | 3.9 (3.61, 4.2) |
| Eastern Europe | 1328.69 (1065.7, 1605.21) | 632.80 (507.55, 764.49) | 395.8 (319.64, 477) | 8.59 (8.33, 8.85) | 46.12 (37.77, 56.57) | 21.97 (17.99, 26.94) | 14.17 (11.57, 17.34) | 4.15 (3.74, 4.56) | 1.64 (1.37, 1.93) | 0.78 (0.65, 0.92) | 0.48 (0.40, 0.57) | 3.39 (3.00, 3.77) |
| Central Asia | 41.06 (33.49, 48.81) | 43.90 (35.81, 52.19) | 53.22 (43.89, 62.92) | 7.24 (7.01, 7.48) | 5.54 (4.67, 6.97) | 5.92 (4.99, 7.45) | 7.45 (6.27, 9.38) | 3.77 (3.44, 4.1) | 0.21 (0.17, 0.26) | 0.22 (0.18, 0.28) | 0.33 (0.27, 0.43) | 3.63 (2.50, 4.76) |
| North Africa and Middle East | 54.3 (43.23, 66.78) | 8.92 (7.10, 10.97) | 10.83 (8.67, 13.35) | 5.92 (5.45, 6.39) | 100.97 (84.2, 119.65) | 16.59 (13.83, 19.66) | 21.11 (17.59, 24.72) | 2.81 (2.69, 2.94) | 3.82 (3.19, 4.44) | 0.63 (0.52, 0.73) | 0.97 (0.81, 1.12) | 2.81 (2.59, 3.04) |
| South Asia | 30.19 (23.68, 37.63) | 1.67 (1.31, 2.08) | 2.03 (1.6, 2.52) | 5.37 (5.07, 5.68) | 190.68 (144.06, 248.6) | 10.56 (7.98, 13.77) | 13.83 (10.63, 17.66) | 3.77 (3.57, 3.97) | 8.75 (6.85, 11.05) | 0.48 (0.38, 0.61) | 0.76 (0.6, 0.95) | 3.77 (3.58, 3.96) |
| South East Asia | 44.73 (35.66, 55.42) | 3.56 (2.78, 4.49) | 2.56 (2.05, 3.15) | 6.35 (5.98, 6.73) | 198.71 (159.21, 254.56) | 5.84 (4.78, 7.45) | 11.82 (9.52, 14.86) | 0.17 (0.05, 0.29) | 9.18 (7.44, 11.5) | 0.25 (0.21, 0.32) | 0.64 (0.52, 0.79) | 0.15 (−0.19, 0.49) |
| East Asia | 891.02 (707.25, 1093.31) | 60.52 (48.04, 74.26) | 42.41 (33.87, 51.68) | 11.96 (11.62, 12.31) | 86.82 (70.96, 103.74) | 5.90 (4.82, 7.05) | 4.36 (3.59, 5.18) | −0.08 (−0.30, 0.14) | 3.23 (2.62, 3.85) | 0.22 (0.18, 0.26) | 0.17 (0.14, 0.20) | −0.53 (−0.79, −0.26) |
| Oceania | 1.13 (0.9, 1.37) | 8.51 (6.81, 10.35) | 18.61 (14.95, 22.75) | 3.62 (1.40, 5.89) | 1.27 (0.82, 1.89) | 9.60 (6.17, 14.2) | 15.58 (10.60, 22.16) | −0.22 (−1.15, 0.72) | 0.04 (0.03, 0.06) | 0.31 (0.21, 0.44) | 0.75 (0.54, 1.04) | −0.27 (−3.03, 2.58) |
| Western sub- Saharan Africa | 3.87 (3, 4.88) | 0.85 (0.66, 1.07) | 1.65 (1.3, 2.04) | 0.82 (−0.13, 1.78) | 31.35 (21.26, 45.26) | 6.87 (4.66, 9.92) | 13.17 (9.11, 18.49) | −0.44 (−0.62, −0.27) | 1.02 (0.71, 1.42) | 0.22 (0.16, 0.31) | 0.55 (0.39, 0.76) | −0.43 (−0.94, 0.09) |
| Eastern sub- Saharan Africa | 2.6 (2, 3.27) | 0.63 (0.49, 0.79) | 1.4 (1.1, 1.74) | 1.37 (0.61, 2.15) | 29.97 (22.89, 39.84) | 7.28 (5.56, 9.67) | 16.91 (13.45, 21.67) | −0.37 (−0.50, −0.23) | 1.20 (0.95, 1.53) | 0.29 (0.23, 0.37) | 0.92 (0.72, 1.21) | −0.36 (−0.79, 0.07) |
| Central sub- Saharan Africa | 0.8 (0.62, 1.01) | 0.61 (0.47, 0.77) | 1.36 (1.08, 1.69) | 1.10 (−0.54, 2.77) | 10.43 (6.84, 15.6) | 7.93 (5.20, 11.86) | 18.97 (13.23, 26.91) | −0.02 (−0.31, 0.27) | 0.41 (0.29, 0.58) | 0.31 (0.22, 0.44) | 1.01 (0.74, 1.36) | −0.01 (−0.86, 0.84) |
| Southern sub- Saharan Africa | 57.4 (44.28, 73.39) | 73.06 (56.35, 93.4) | 94.86 (72.97, 120.7) | 8.87 (8.42, 9.32) | 9.74 (8.36, 11.08) | 12.40 (10.65, 14.1) | 17.24 (14.86, 19.32) | 0.02 (−0.13, 0.17) | 0.43 (0.37, 0.48) | 0.55 (0.47, 0.61) | 0.96 (0.82, 1.07) | −0.14 (−0.76, 0.48) |
CAVD, calcific aortic valve disease; 95% UI, 95% uncertainty intervals; 95% CI, 95% confidence interval.