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. Author manuscript; available in PMC: 2023 Aug 7.
Published in final edited form as: Nature. 2023 Apr 12;616(7958):747–754. doi: 10.1038/s41586-023-05857-4

Extended Data Fig. 2. Association of CHIP with chronic liver disease.

Extended Data Fig. 2

a, Association of CHIP with prevalent or incident chronic liver disease by variant allele fraction. b, Association of CHIP with chronic liver disease by mutated gene. c, Cumulative risk of chronic liver disease by clonal hematopoiesis status in the UK Biobank. d, Cumulative risk of chronic liver disease by clonal hematopoiesis status in the UK Biobank by age 80 years. Estimates derived using logistic regression with adjustment for age and sex in the UK Biobank, Framingham Heart Study and Atherosclerosis Risk in Communities study and pooled using inverse variance weighted fixed effects meta-analysis. Cumulative risk of chronic liver disease by age was modeled using Cox proportional hazards model with age as the underlying time variable and adjustment for sex. CHIP, clonal hematopoiesis of indeterminate potential; CI, 95% confidence interval; OR, odds ratio; VAF, variant allele fraction.