Table 1. Baseline characteristics of participants in samples analysed.
Summary of cohort characteristics in studies used for analysis of CHIP and chronic liver disease. ARIC, Atherosclerosis Risk in Communities study; BMI, body-mass index; FHS, Framingham Heart Study; MGB, Mass General Brigham; n, number; s.d., standard deviation; WES, whole exome sequencing; NA, not available.
| Characteristics | FHS, n = 4,230 |
ARIC, n = 7,414 |
UK Biobank WES, n = 201,409 |
UK Biobank Array, n = 239,316 |
MGB Biobank, n = 1,482 |
|---|---|---|---|---|---|
| Age (mean years (s.d.)) | 61.1 (15.7) | 57.4 (6.0) | 56.5 (8.1) | 57.0 (8.1) | 53 (12) |
| Women (n (%)) | 2,292 (54%) | 4,358 (56%) | 110,192 (55%) | 127,600 (53%) | 871 (59%) |
| BMI (mean kg/m2 (s.d.)) | 27.8 (5.5) | 27.7 (5.4) | 27.4 (4.8) | 27.4 (4.8) | NA |
| Current smoking (n (%)) | 610 (15%) | 1,992 (26%) | 13,358 (7%) | 20,819 (9%) | NA |
| Alcohol intake (mean drinks per week (s.d.)) | 6.8 (16.6) | 5.6 (8.8) | 7.9 (9.8) | 8.1 (10.3) | 4.4 (7.4) |
| History of diabetes mellitus (n (%)) | 166 (4%) | 674 (9%) | 9,676 (5%) | 12,438 (5%) | 95 (7%) |
| CHIP prevalence (n (%)) | 369 (9%) | 333 (4%) | 11,783 (5%) | 189 (0.1%) | 90 (6%) |
| CHIP≥10% prevalence (n (%)) | 342 (8%) | 267 (4%) | 6,188 (3%) | 189 (0.1%) | 51 (4%) |