Fig. 3.

The role of SYNPO2 in Hippo pathway signaling. The left part shows that low SYNPO2 or abnormal SYNPO2 expression increases the nuclear importation of YAP, leading to the activation of transcriptional factors such as TEAD and KLF5, which promotes cancer stemness and resistance to oxidative stress. The right part indicates that high SYNPO2 expression promotes the phosphorylation of YAP, resulting in the cytoplasmic localization of YAP and the inactivation of its co-transcription